The Global Framework on Chemicals - For a Planet Free of Harm from Chemicals and Waste (GFC), provides the essential building blocks for a future in which humanity benefits from chemicals in a safe and sustainable manner, while avoiding their negative impacts. The Framework, adopted in September 2023 at the fifth International Conference on Chemicals Management (ICCM5), seeks to protect both the planet and human health, advocating for strong governance mechanisms and enforcing international standards. The Framework presents a comprehensive plan with five strategic objectives and 28 targets to guide countries and stakeholders in jointly addressing the lifecycle of chemicals, including products and waste. This unique multi-stakeholder agreement brings in a variety of sectors including representatives from governments, the private sector, non-governmental and intergovernmental organizations, youth and academia. It is supported by the Bonn Declaration, a high-level declaration also agreed at ICCM5 in Bonn, Germany.